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超脂血症和肥胖症之间的协同相互作用是美国人压力尿失禁的危险因素
Fangyi Zhu1, Mao Chen1, Ya Xiao1
1Department of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
Scientific reports
|March 28, 2024
概括
超脂血症显著增加了肥胖妇女的压力尿失禁的风险,具有显著的协同效应. 禁食甘油三是一个关键指标,特别是在50岁以下的女性.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 尿失禁 (UI) 在中年和老年妇女中普遍存在,影响健康并造成社会成本.
- 肥胖是已知的UI风险因素,经常与高脂血症同时发生.
- 超脂血症在女性UI中的特定作用仍未得到充分探索.
研究的目的:
- 评估高体重指数 (BMI) 和高脂血与美国女性UI的独立关联.
- 评估肥胖和高脂血症之间对UI风险的附加相互作用.
主要方法:
- 利用了2005-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 使用加权多变量逻辑回归模型.
- 通过使用相对过度风险因相互作用 (RERI),相互作用的归因比例 (AP) 和协同作用指数 (S) 来评估添加性相互作用.
主要成果:
- 超脂血症与肥胖女性的压力尿失禁 (SUI) 风险增加有关 (OR=1.52).
- 在SUI上观察到超脂血症和肥胖之间存在显著的协同效应 (调整后的RERI:3.75).
- 禁食血清甘油三化物成为SUI风险的最相关的脂质指标,特别是在50岁以下的肥胖女性中.
结论:
- 超脂血是肥胖女性SUI的独立危险因素.
- 肥胖和高脂血症在SUI方面表现出协同作用的关系.
- 针对性脂肪管理,重点关注甘油三,可能有利于SUI患者,特别是年轻的肥胖女性.
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