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循环TNF受体水平与估计的淋巴细胞过率有关,即使在正常功能健康个体中也是如此
Tomohito Gohda1, Maki Murakoshi2, Terumi Shibata2
1Department of Nephrology, Juntendo University Faculty of Medicine, Hongo 2-1-1, Bunkyo-Ku, Tokyo, 113-8421, Japan. goda@juntendo.ac.jp.
Scientific reports
|March 28, 2024
概括
血清瘤缩因子受体 (TNFR) 水平与健康成人和糖尿病患者的功能有关. 较高的TNFR水平与较低的估计质过率 (eGFR) 相相关,特别是在糖尿病患者中.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 血清瘤缩因子受体 (TNFR) 水平,特别是TNFR1和TNFR2,与糖尿病患者的功能有关.
- 然而,这种关联以及年龄和性别对正常功能健康个体TNFR水平的影响仍未得到充分研究.
研究的目的:
- 在健康人群中,研究血清TNFR1和TNFR2水平与估计的淋巴细胞过率 (eGFR) 之间的关系.
- 检查年龄和性别对健康个体TNFR水平的影响.
- 为了比较健康人和2型糖尿病患者之间的TNFR水平.
主要方法:
- 在413名健康受试者和292名2型糖尿病患者中测量了TNFR1和TNFR2的血清水平.
- 使用多变量分析来评估TNFR水平,eGFR (基于cystatin C),年龄,性别和其他临床因素之间的关联.
- 在健康个体和糖尿病患者之间进行了比较,并在健康队列内根据年龄和性别进行了比较.
主要成果:
- 在健康人群中,TNFR水平与性别没有差异,但TNFR2水平随年龄增加.
- 无论是TNFR1和TNFR2,都与较低的eGFR相关 (eGFR-CysC<90mL/min/1.73m2),即使经过对临床因素的调整.
- TNFR1与eGFR-CysC相关,而TNFR2与eGFR-CysC和静脉压相关.
- 当两组组合时,糖尿病和高糖血红蛋白是TNFR水平的重要决定因素.
- 与健康人相比,糖尿病患者的TNFR水平通常更高.
结论:
- 血清TNFR水平与健康个体的功能 (eGFR-CysC) 有关,不论年龄和性别.
- 在2型糖尿病患者中,TNFR水平升高,并受到血糖控制的影响.
- 这些发现表明TNFRs可能在功能下降中发挥作用,特别是在糖尿病的背景下.
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