使用病例交叉设计,COVID-19疫苗和流产发作之间缺乏关联
Irati Gastesi Orbegozo1, Lucía Cea-Soriano2, Ana Llorente3
1Biomedical Research Foundation Hospital 12 de Octubre, Instituto de Investigación 12 de Octubre (imas12), Madrid, Spain.
Scientific reports
|March 28, 2024
概括
这项研究发现,在接种COVID-19疫苗后,流产风险总体没有增加. 然而,结果因接收的疫苗剂量数量而异,因此需要使用更大的样本大小进行进一步调查.
科学领域:
- 产科和妇科 产科和妇科
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- 孕妇面临SARS-CoV-2感染风险的增加.
- 关于COVID-19疫苗安全性和流产等怀孕不良事件的知识差距存在.
研究的目的:
- 在现实世界中探索COVID-19疫苗接种与流产风险之间的关联.
- 评估疫苗剂量数对流产风险的影响.
主要方法:
- 在西班牙的BIFAP数据库中使用了4054例接种疫苗的孕妇队列的案例交叉设计.
- 对间歇性疫苗暴露的流产病例 (N=607) 进行了分析.
- 调整的赔率比率是使用条件后勤回归和通用线性混合效应模型计算的.
主要成果:
- 与COVID-19疫苗接种相关的流产总体风险没有增加.
- 一次剂量 (aOR1.65) 观察到略高的风险,但两次剂量 (aOR1.02) 没有.
- 在两种分析方法中,结果一致.
结论:
- COVID-19疫苗似乎没有增加流产的整体风险.
- 关于剂量数量的矛盾发现表明需要进一步研究.
- 需要更大的样本大小来最终评估COVID-19疫苗接种和流产之间的关联.
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