大脑的微观结构与早期多发性硬化症的认知疲劳有关
Camille Guillemin1,2, Nora Vandeleene1, Maëlle Charonitis1,2
1GIGA-CRC In Vivo Imaging, University of Liège, Liège, Belgium.
Journal of neurology
|March 28, 2024
概括
大脑微观结构的变化在多发性硬化症 (MS) 的早期存在,并与认知疲劳有关. 这些看起来正常的大脑组织的变化可能解释了MS患者经历的疲劳.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 多发性硬化症研究研究
背景情况:
- 认知疲劳是多发性硬化症 (MS) 的主要症状,影响患者在疾病的早期.
- 了解与认知疲劳相关的早期大脑变化对于管理MS进展至关重要.
研究的目的:
- 与健康对照组 (HC) 相比,研究MS (pwMS) 患者大脑微观结构的早期变化.
- 确定这些微观结构变化与pwMS中的认知疲劳之间的关联.
主要方法:
- 对最近诊断的pwMS进行了定量多参数映射 (MTsat,PD,R1,R2*),并与HC匹配.
- 微观结构参数被分析为正常出现的白质 (NAWM),皮质灰质 (NACGM) 和深灰质 (NADGM).
- 统计分析包括贝叶斯的T测试和通用线性混合模型来比较组和评估关联.
主要成果:
- 与HC相比,pwMS在NAWM和NACGM中显示MTsat和R1降低,NADGM中的R1增加.
- 认知疲劳与所有组织的PD相关,在NAWM中MTsat.
- 疾病特异性相关性表明,NAWM和NACGM中改变的微观结构与 pwMS中的疲劳有关.
结论:
- 即使在MS的早期阶段,在看起来正常的组织中,大脑的微观结构也发生了变化.
- 广泛的微观结构变化,潜在的脱髓化或轴突退化,可能是 pwMS 认知疲劳的基础.
相关概念视频
01:19Multiple Sclerosis l: Introduction
20
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
20
01:23Alzheimer Disease ll: Pathophysiology
35
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
35