循环非经典单细胞的高频率与复发性复发性多发性硬化症的稳定缓解有关
Misako Minote1,2, Wakiro Sato1,3,4, Kimitoshi Kimura1,2
1Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
Immunological medicine
|March 28, 2024
概括
非经典单细胞 (NCM) 和激活调节性T细胞 (Tregs) 是维持无多发性硬化症 (MS) 没有疾病活性证据 (NEDA) 的关键. 较高的NCM水平预测RRMS患者的长期疾病稳定性.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
背景情况:
- 没有疾病活性证据 (NEDA) 是多发性硬化症 (MS) 患者的关键治疗目标.
- 维持长期NEDA的潜在生物机制仍然不完全理解.
- 研究免疫细胞子集可能会阐明持续疾病稳定性的途径.
研究的目的:
- 澄清复发性复发性硬化症 (RRMS) 长期疾病稳定性的免疫学基础.
- 为了确定与维持NEDA状态相关的特定循环免疫细胞子集.
- 探索MS缓解中的非经典单细胞 (NCM) 和调节性T细胞 (Tregs) 之间的功能关系.
主要方法:
- 流细胞测量用于分析RRMS患者的循环免疫细胞子集,有或没有疾病活性证据.
- 进行了共同培养试验,以评估NCM和Tregs之间的相互作用.
- 使用了统计分析,包括相关性和预测价值评估 (AUC).
主要成果:
- 与活跃疾病患者相比,长期患有NEDA的患者表现出非经典单细胞 (NCM) 和激活调节性T细胞 (Tregs) 的频率显著更高.
- NCM频率和NCM与古典单细胞 (NCM/CM) 的比率与激活的Treg频率和NEDA持续时间正相关.
- 在共同培养试验中,NCM被证明可以增强Treg频率和PD-L1表达,NEDA患者NCM的PD-L1更高.
- NCM频率和NCM/CM比率显示出疾病稳定性的高预测值 (AUC分别为0.97和0.94).
结论:
- 非经典单细胞 (NCM) 在实现和维持RRMS患者稳定缓解方面发挥着重要作用.
- 通过增加调节性T细胞 (Tregs) 的频率和激活,NCM可以促进疾病的稳定性.
- 在RRMS中,NCM频率和NCM/CM比率是预测长期NEDA状态的有希望的生物标志物.
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