患有血友病的老年人的挑战
Michael Makris1, Riitta Lassila2, Megan Kennedy3
1School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
概括
随着遗传性出血障碍的治疗方法的改进,更长的寿命带来了诸如血栓形成和持续的肌肉骨疼痛等新的挑战. 管理这些复杂的问题需要一个以人为中心的协作方法,以获得最佳的生活质量.
科学领域:
- 老年病的医生 老年病的医生
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 对遗传性出血障碍的改善治疗方法正在增加患者的预期寿命.
- 这种人口变化引入了与年龄相关的健康问题,包括血栓形成和慢性疼痛,进入出血障碍人口中.
研究的目的:
- 审查在患有遗传出血障碍的个体中治疗血栓的复杂性.
- 要突出肌肉骨疼痛在老年患者血友病和并发症的持续挑战.
主要方法:
- 关于与高凝血因子水平和非因子治疗相关的血栓形成风险的文献综述.
- 对患有血友病和多种并发症的老年人疼痛管理策略的分析.
主要成果:
- 低凝血因子水平与出血风险之间,以及高水平/某些疗法与血栓形成风险之间存在着公认的关联.
- 这种人群中血栓形成的管理是复杂的,但可以通过现代治疗和协作决策来实现.
- 肌肉骨疼痛仍然是患有血友病的老年人中的一个重要问题,影响生活质量.
结论:
- 在遗传性出血障碍中有效地治疗血栓形成需要涉及医疗保健专业人员和患者的多学科方法.
- 一个以人为中心,整体和多学科的战略对于管理慢性疼痛和优化血友病和并发症的老年人功能至关重要.
相关概念视频
Disorders of Hemostasis
885
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
885
Anticoagulant Drugs: Low-Molecular-Weight Heparins
690
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
690
Aging
49
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
49
Introduction to Hemostasis
7.6K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
7.6K
Humoral Immune Responses
72.7K
Overview
72.7K
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K


