认知测试和综合测试的纵向规范标准使用了来自威斯康星州两个AD风险丰富队列的协调数据
Erin M Jonaitis1,2, Bruce P Hermann3, Kimberly D Mueller4,5
1Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, Wisconsin, USA.
概括
新的阿尔茨海默氏病 (AD) 规范可以发现早期的认知变化. 使用量子回归开发的纵向标准显示,残疾或AD生物标志物的个体得分较低,有助于早期检测.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 生物统计学 生物统计学
背景情况:
- 当前的认知规范往往无法检测早期的,临床前痴呆症变化.
- 阿尔茨海默氏病 (AD) 研究需要敏感的措施来早期发现.
研究的目的:
- 开发和验证认知措施的人口调整,横截面和纵向规范标准.
- 创建对阿尔茨海默病临床前认知变化敏感的标准.
主要方法:
- 来自两个阿尔茨海默氏症风险丰富队列 (威斯康星州阿尔茨海默氏症预防注册和威斯康星州阿尔茨海默氏症研究中心) 的综合数据.
- 使用量子回归来建立无条件 (截面) 和条件 (纵向) 的规范标准,用于认知无损参与者的18个认知结果 (N=1390).
- 进行了有效性分析 (N=2456),对认知状态和AD生物标志物进行百分点评分.
主要成果:
- 在基于共识的认知障碍或AD生物标志物呈阳性的人群中,横截面和纵向百分位数得分都较低.
- 较高的定量AD生物标志物水平与较低的百分位数得分相关,表明认知能力下降.
结论:
- 该研究成功地制定了对临床前AD相关变化敏感的认知指标的规范标准.
- 未来的研究将集中在这些纵向规范标准的临床实用性,用于早期发现AD.
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