处理速度的下降只是故事的一半:在患有状细胞疾病的儿童中发育延迟
Elise Jade Walker1, Fenella Jane Kirkham1,2, Anna Marie Hood3
1Developmental Neurosciences Unit, Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
Children (Basel, Switzerland)
|March 28, 2024
概括
患有状细胞疾病 (SCD) 的儿童随着时间的推移显示处理速度下降,这表明潜在的发育延迟. 早期监测处理速度对于儿童SCD患者的及时干预至关重要.
科学领域:
- 儿科神经学 儿科神经学
- 神经科学是一个神经科学.
- 血液学 血液学 血液学
背景情况:
- 状细胞疾病 (SCD) 与儿童的认知障碍有关.
- 处理速度是儿童SCD中经常受到影响的认知领域.
- 患有SCD的儿童处理速度的纵向变化尚未得到充分理解.
研究的目的:
- 研究状细胞疾病儿童处理速度的纵向变化.
- 检查诊断时的年龄和处理速度轨迹之间的关系.
- 确定影响儿科SCD处理速度下降的潜在因素.
主要方法:
- 一组103名患有SCD的儿童 (3-16岁) 在1992-2001年期间接受了认知评估,其中一些完成了后续评估.
- 使用线性混合效应建模来分析处理速度指数 (PSI) 的重复测量.
- 该研究控制了MRI检测到的心脏病状况 (无声心脏病或中风),并检查了年龄和评估时间点之间的相互作用.
主要成果:
- 随着时间的推移,患有SCD的儿童的处理速度指数 (PSI) 随着时间的推移而下降,无论最初的年龄组 (≤8.99或≥9.00岁).
- 处理速度编码子测试显示了最显著的下降.
- 评估时间点和年龄之间的显著相互作用表明,随着年龄的增长,处理速度的下降变得更加明显,可能反映出发育迟缓.
结论:
- 患有状细胞疾病的儿童的处理速度在纵向下降,这表明与疾病进展相关的潜在发育延迟.
- 尽管SCD治疗方面取得了进展,但处理速度仍然令人担忧.
- 建议对处理速度进行临床监测,以尽早识别儿科SCD的延迟和干预.
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