由p53瘤抑制剂的功能障碍引起的瘤进展的动素依赖机制

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Updated: Jun 29, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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Natalia Khromova1, Maria Vasileva1, Vera Dugina1,2,3

  • 1Carcinogenesis Institute, N.N. Blokhin National Medical Research Oncology Center, The Ministry of Health of Russia, 115478 Moscow, Russia.

Cancers
|March 28, 2024
PubMed
概括

通过改变actin细胞骨架动态,增加细胞迁移和入侵,p53功能障碍促进癌症的攻击性. 恢复野生型TP53抑制了这些恶性行为,提供了新的治疗见解.

关键词:
这就是TP53的特点.作为一种actin的单体形式.细胞骨架 细胞骨架瘤进展的进展情况

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