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Yasmine Ghantous¹, Shiraz Mozalbat², Aysar Nashef¹

¹Department of Oral and Maxillofacial Surgery, Tzafon Medical Center, Faculty of Medicine, Bar Ilan University, Ramat Gan 5290002, Israel.

|March 28, 2024

概括

像N-cadherin这样的表皮-介质细胞过渡 (EMT) 标志物预测了口腔状细胞癌 (OSCC) 中的淋巴结转移. 针对EMT可能会防止癌症扩散并改善患者的治疗结果.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
分子病理学分子病理学

背景情况:

表皮-介质细胞过渡 (EMT) 对于瘤入侵和口腔状细胞癌 (OSCC) 的转移至关重要.
EMT涉及细胞粘附的损失和迁移性质的获取,其特征是卡德林切换 (例如,降低E-cadherin,增加N-cadherin).
TGF-β/SMAD通路与诱导EMT有关.

研究的目的:

研究EMT标记物作为OSCC中淋巴结转移的预测剂的作用.
分析EMT标记物和TGF-β/SMAD通路基因与瘤阶段和淋巴结状况相关的表达.

主要方法:

来自TCGA的159个OSCC初级样本的基因分析.
对EMT标记物 (cadherin开关基因) 和TGF-β/SMAD通路基因的分析.
使用新鲜的OSCC样本进行差异表达分析和独立验证.

主要成果:

在晚期瘤 (III-IV) 中对TGF-β/SMAD通路基因 (例如,SMAD6) 的升调.
在节点阳性OSCC瘤中过度表达N-cadherin和SNAIL2.
在晚期和结节阳性瘤中低调质素.

结论:

在OSCC中,EMT标记物的表达与淋巴结转移有显著的相关性.
N-cadherin和其他EMT调节剂是预防转移的潜在治疗点.
针对EMT途径可以改善OSCC患者的临床结果.

关键词:

在EMT中,EMT是EMT.这是一种N-cadherin.淋巴结的淋巴结是指淋巴结的口腔癌是口腔癌的一个组成部分.

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