在SARS-CoV-2感染后的主观认知障碍中的Co-ultraPEALut:一项探索性回顾性研究
Valentina Cenacchi1, Giovanni Furlanis1, Alina Menichelli2
1Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste-ASUGI, University of Trieste, Strada di Fiume, 447, 34149 Trieste, Italy.
Brain sciences
|March 28, 2024
概括
在COVID-19后出现神经症状的患者中,同ultraPEALut治疗显著改善了认知功能和记忆力. 这表明调节神经炎症是治疗长期COVID认知障碍的关键.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- COVID-19的神经并发症通常与神经炎症有关.
- 作为抗炎剂的Co-ultraPEALut和抗氧化剂的卢托林显示出在控制神经炎症方面的潜力.
- 在COVID-19后的条件下,认知障碍是一个重大挑战.
研究的目的:
- 评估co-ultraPEALut在治疗COVID-19后神经障碍患者的认知障碍中的疗效.
- 在10个月的时间内评估记忆,疲劳和整体认知功能的变化.
主要方法:
- 一项回顾性研究,将接受co-ultraPEALut治疗的患者与对照组进行比较.
- 用蒙特利尔认知评估 (MoCA) 和前回顾性记忆问卷 (PRMQ) 评估认知功能.
- 疲劳严重程度量表 (FSS) 和主观患者评估也在基线和10个月后被使用.
主要成果:
- 接受co-ultraPEALut的患者在PRMQ得分 (p < 0.00001) 和MoCA原始得分 (p = 0.0260) 中显著改善.
- 虽然MOCA调整后的分数和FSS显示有所改善,但这些都没有统计学意义.
- 80.77%的co-ultraPEALut患者报告主观认知改善,而对照组的变化不那么明显.
结论:
- 协同ultraPEALut治疗似乎有效改善神经后COVID-19患者的认知和记忆缺陷.
- 这些发现支持这样一个假设:调节神经炎症对于管理长时间的COVID神经病情后续至关重要.
- 在COVID-19感染后的认知功能障碍中,Co-ultraPEALut可能是一个有价值的治疗选择.
相关概念视频
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:30Negative and Cognitive Symptoms of Schizophrenia
48
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
48
01:23Assessment of the Cardiovascular System I: Subjective Data
323
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
323
01:20COPD: Pathogenesis and Clinical Features
269
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
269
01:26Alzheimer's Disease: Overview
469
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
469
01:24Prosopagnosia
161
Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
161