超越死亡率:探讨植物基对调节铁亡的影响 - - 一个系统性审查
Nemanja Živanović1, Marija Lesjak1, Nataša Simin1
1Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia.
Antioxidants (Basel, Switzerland)
|March 28, 2024
概括
聚醇显著影响铁亡,这是一种与疾病相关的细胞死亡途径. 本综述详细介绍了植物化合物如何诱导或抑制铁,从而提供治疗潜力.
科学领域:
- 生物化学和分子生物学
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 铁亡是一种独特的编程细胞死亡形式,其特点是铁的积累,反应性氧物种,谷氨酸的枯竭和脂质过氧化.
- 铁亡与各种疾病有关,包括神经退行性疾病,缺血/再损伤,癌症和慢性病.
- 多,植物衍生化合物具有多样化的生物活性,越来越多地研究它们在调节铁亡中的作用.
研究的目的:
- 系统地审查有关多对铁亡的影响的文献.
- 识别可以诱导或抑制铁亡的化合物,并阐明它们的作用机制.
主要方法:
- 从2017年到2023年11月,在Scopus,Web of Science,PubMed,ScienceDirect和Springer进行了广泛的文献搜索.
- 关键词包括"ferroptosis"与各种多类 (黄类,酸,stilbene,库马林, antraquinone, chalcone) 结合在一起.
- 分析了311篇论文和143种化合物.
主要成果:
- 在143种化合物中,发现53种诱导了铁亡,110种抑制了铁亡.
- 根据实验系统,有20种化合物表现出诱导和抑制铁亡的双重能力.
- 什科宁,黄素,奎尔丁,白醇和贝卡林是最常被研究的化合物.
结论:
- 聚醇在调节铁亡方面表现出显著的潜力,许多化合物能够诱导或抑制这种细胞死亡途径.
- 常见的机制包括Nrf2/GPX4和Nrf2/HO-1轴的调节,以及铁代谢.
- 这些发现突出了多作为治疗策略的有希望的候选人,针对与铁死相关的疾病.
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