阿司匹林欧根醇对肝脏氧化损伤和能量代谢在免疫应激的肉的影响
Jiale Zhong1, Wenrui Zhen1,2, Dongying Bai1,2
1Department of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China.
Antioxidants (Basel, Switzerland)
|March 28, 2024
概括
阿司匹林尤根醇 (AEE) 补充剂通过减少氧化应激和炎症来改善生长并保护免疫应激的肉免受肝损伤. 它还对能量代谢和营养物质加工产生积极影响.
科学领域:
- 动物科学动物科学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 肉的免疫应激会导致肝脏氧化损伤和代谢功能障碍,影响动物的健康和生产力.
- 了解这些影响背后的分子机制对于开发有效的营养策略至关重要.
研究的目的:
- 为了研究阿司匹林尤根醇 (AEE) 对肝脏氧化损伤和受到免疫应激的 brojlers 的能量代谢的影响.
- 评估AEE对免疫应激肉生长性能,抗氧化能力,炎症标志物和代谢途径的影响.
主要方法:
- 312只肉被分为四组:盐水控制,脂聚糖 (LPS) 诱导的免疫应激,以及在免疫应激下补充AEE (0.01%) 的两组.
- 分析了生长参数,肝脏抗氧化剂指数,炎症基因表达 (PTGS2,IL-1β),氧化酸化标志物和代谢概况.
主要成果:
- 服用AEE补充剂显著改善了体重,平均每日增加和料摄入量,同时降低了免疫应激肉的料转换率.
- 通过增加总抗氧化剂容量,超氧化物脱酶活性,GSTA3和GLRX2表达,以及减少甲 (MDA),AEE保护了肝脏.
- 通过降低前列腺素-F2α,PTGS2和IL-1β表达,AEE减少了炎症,通过调节氧化酸化,改善了能量代谢,改变了脂质和氨基酸代谢.
结论:
- 阿司匹林尤根醇 (AEE) 有效地减轻免疫应激的 brojlers 肝脏氧化损伤和能量代谢障碍.
- AEE对肉生长性能和免疫反应具有显著的益处,使其成为潜在的料添加剂.
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