对抗氧化化合物-硫酸 (PTSO) 的两代毒性研究
Antonio Cascajosa-Lira1, Remedios Guzmán-Guillén1, Silvia Pichardo1
1Área de Toxicología, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain.
Antioxidants (Basel, Switzerland)
|March 28, 2024
概括
基硫酸盐 (PTSO) 在两代小鼠中没有显示出生殖或发育毒性. 这种在Allium物种中发现的天然化合物,在食品,料和农业中潜在使用似乎是安全的.
科学领域:
- 毒理学 毒理学 毒理学
- 生殖毒理学 生殖毒理学
- 食品安全 食品安全
背景情况:
- -硫酸盐 (PTSO) 是一种来自Allium物种的有机硫化合物.
- 作为食品/料的天然添加剂和生物杀虫剂,PTSO正在被探索.
- 毒理学评估对于PTSO在牲畜,消费者和环境中的安全至关重要.
研究的目的:
- 评估PTSO在小鼠中的生殖和发育毒性.
- 根据经合组织416指南,评估潜在的原性和遗传性影响.
- 为支持PTSO在农业食品部门的应用进行风险评估.
主要方法:
- 在CD1小鼠中进行两代生殖毒性研究 (80/性别/一代).
- 在孕前期,孕期和哺乳期,PTSO通过料以14,28和55 mg/kg体量/天的剂量进行.
- 评估生殖表现,后代发育,激素水平,精子分析,器官重量和组织病理学.
主要成果:
- 没有观察到与治疗相关的死亡率或临床症状.
- 轻微的,不取决于性别或剂量的体重和食物消耗的变化.
- 正常的生殖能力,对后代没有原性或遗传性影响.
- 激素水平,器官重量和组织病理学没有受到影响.
- 精子分析仅显示F0的变化,而不是F1;没有生育能力的改变.
结论:
- 在测试条件下,PTSO在小鼠中不被认为是生殖或发育毒素.
- 这项研究支持PTSO在农业食品行业的安全概况.
- 结果表明PTSO对牲畜,消费者和环境应用的安全性.
关键词:
属 (Allium sp.) 是一种植物.抗氧化剂是一种抗氧化剂.在活体中,活体内.自然添加剂是一种自然添加剂.有机硫化合物 有机硫化合物安全评估安全评估的安全评估.硫酸硫酸硫酸硫酸硫酸硫酸硫酸硫酸硫酸硫酸硫酸.两代人的毒性毒性更多相关视频
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