在接受康复治疗的亚急性中风患者中,系统性氧化应激
Carola Cocco1, Mariacristina Siotto1, Alessandro Guerrini1,2
1IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy.
Antioxidants (Basel, Switzerland)
|March 28, 2024
概括
亚急性中风患者呈现高氧化应激,在康复后有所改善. 监测氧化应激可以个性化中风恢复干预措施,以获得更好的功能结果.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 康复医学 康复医学 康复医学
背景情况:
- 氧化应激在急性中风中得到了很好的研究,但在亚急性阶段的研究较少.
- 在亚急性中风恢复期间了解氧化应激动态对于优化患者的治疗结果至关重要.
研究的目的:
- 分析六周康复计划之前和之后的亚急性中风患者全身氧化状态的变化.
- 研究系统氧化状态与康复结果之间的关系,包括日常生活活动,手握力和行走耐力.
主要方法:
- 在两个中心招募了109名亚急性中风患者.
- 测量了氧化物 (d-ROMs),生物抗氧化能力 (BAP) 和硫醇抗氧化成分 (-SHp) 的血清水平.
- 使用相对抗氧化能力指数 (OSI,SH-OSI),修改后的巴特尔指数,手握测试和6分钟步行测试来评估结果.
主要成果:
- 大多数患者在基线 (T0) 呈现高d-ROM和低于最佳的抗氧化剂指数.
- 经过六周的康复 (T1),d-ROMs,OSI和SH-OSI指数显著改善.
- 康复结果,包括日常生活活动,手握力和行走耐力,也显示出显著的改善.
- 在氧化应激标志物和功能恢复之间发现了相关性.
结论:
- 系统性氧化应激状态在亚急性中风恢复期间发生变化.
- 监测氧化应激可以帮助为中风后患者量身定制康复干预措施.
- 解决氧化应激与中风后功能恢复的改善有关.
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