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Renewal of Intestinal Stem Cells01:23

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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YAP1/TAZ调解皮上皮细胞增殖,但不能在体外进行短链脂肪酸代谢.

Bin Yang1,2,3, Zebang Xu2,3, Hongwei Chen2,3

  • 1School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.

Animals : an open access journal from MDPI
|March 28, 2024
PubMed
概括

Yes1关联蛋白 (YAP1) 和含有WW域的转录调节蛋白1 (TAZ) 促进皮表皮细胞的增殖. 然而,这些关键的调节剂并没有影响甲酸诱导的乳头发育或短链脂肪酸代谢.

关键词:
在GA-017中,GA-017是指GA-017的位置.雅普1 / 塔兹它们的扩散和扩散.皮上皮细胞是 rumen 的上皮细胞.甲酸盐和甲酸盐的使用方法形形形形形形

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科学领域:

  • 动物生理学 动物生理学
  • 分子生物学分子生物学
  • 蜂信号传输是如何进行的

背景情况:

  • 的发育对于反动物的健康和生长至关重要.
  • Yes1关联蛋白 (YAP1) 和含有WW域的转录调节蛋白1 (TAZ) 对哺乳动物上皮的调节至关重要.
  • 了解YAP1/TAZ在皮上皮中的作用是改善畜牧业的关键.

研究的目的:

  • 为了研究YAP1/TAZ对皮上皮 (RE) 细胞增殖的影响.
  • 为了确定YAP1/TAZ信号是否介导由甲酸 (SB) 诱导的发育.
  • 探索RE细胞中YAP1/TAZ,Hippo,Wnt和信号通路之间的关系.

主要方法:

  • 使用GA-017 (GA) 来激活YAP1/TAZ和脊素 (VP) 来抑制RE细胞中的YAP1/TAZ.
  • 评估RE细胞增殖和基因表达的变化.
  • 研究了SB对具有和没有YAP1/TAZ调制的RE细胞的影响.

主要成果:

  • GA增强了RE细胞的增殖,而VP则抑制了它,这表明YAP1/TAZ在增殖中的作用.
  • YAP1/TAZ激活改变了Hippo,Wnt和信号通路,增加了CCN1/2的表达.
  • 抑制YAP1/TAZ降低了BIRC3的表达.
  • SB治疗促进了RE细胞分化和短链脂肪酸 (SCFA) 代谢基因表达,独立于YAP1/TAZ活性.

结论:

  • YAP1/TAZ是调节RE细胞增殖的潜在目标.
  • YAP1/TAZ似乎没有调解SB诱导的RE发育或SCFA代谢.
  • SB不会影响YAP1/TAZ的活动,这表明在RE开发中存在不同的监管机制.