高密度脂蛋白对癌症风险的保护作用:专注于多发性髓瘤
Alessandro Allegra1, Giuseppe Murdaca2,3, Giuseppe Mirabile1
1Hematology Unit, Department of Human Pathology in Adulthood and Childhood "Gaetano Barresi", University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Biomedicines
|March 28, 2024
概括
癌细胞为生长和生存重新编程脂质新陈代谢. 本综述探讨了多发性骨髓瘤中改变的脂质通路如何影响瘤进展和药物反应,揭示了新的治疗点.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 代谢途径 代谢途径
背景情况:
- 脂肪代谢在癌症中发生了根本性的改变,影响了瘤发生.
- 脂质对癌细胞信号传递,膜结构,能量和免疫逃逸至关重要.
- 代谢变化会影响关键的癌症过程,如炎症,氧化应激和血管生成.
研究的目的:
- 审查癌症中脂质代谢的修改,特别关注多发性骨髓瘤.
- 阐明改变的脂质通路如何影响多发性骨髓瘤细胞生长,生存和药物敏感性.
- 探索脂肪代谢在瘤微环境中的作用,并确定治疗策略.
主要方法:
- 在癌症和多发性髓瘤中对脂质代谢的文献综述.
- 分析特定的脂质通路如何影响癌细胞行为.
- 识别多发性骨髓瘤脂质代谢中的弱点和可药物点.
主要成果:
- 癌细胞在脂质代谢中表现出显著的变化,这对于它们的生存和增殖至关重要.
- 多发性骨髓瘤中的特定脂质通路失调影响恶性血细胞表型,生长和耐药性.
- 瘤微环境中的相互作用是由癌症相关的脂质变化调节的.
结论:
- 脂质代谢重编程是癌症的标志,在多发性骨髓瘤中尤其明显.
- 准脂质脆弱性是一个有前途的治疗策略,用于多发性骨髓瘤.
- 了解这些代谢依赖关系可以为多发性骨髓瘤护理带来新的治疗方法.
相关概念视频
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Differentiation of Common Myeloid Progenitor Cells
3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K


