对益生菌和肝胆道疾病的最新见解
Xiaoyu Xu1, Cheng Zhang1, Guoyi Tang1
1School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China.
Biomedicines
|March 28, 2024
概括
益生菌在改善肠道健康和肠 - 肝轴的过程中,在治疗肝脏疾病方面表现有前途. 需要进一步的研究,以优化它们在临床实践中用于各种肝胆道疾病的使用.
科学领域:
- 胃肠病学和肝病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肝胆道疾病在全球普遍存在,影响肝脏和胆道系统.
- 肠道微生物群失调与代谢和免疫功能障碍有关,增加了像NAFLD,ALD,NASH和HCC这样的肝脏疾病的风险.
- 肠肝轴在维持肝脏健康方面发挥着至关重要的作用,其破坏与疾病的发病有关.
研究的目的:
- 审查2018-2023年间对肝胆道疾病的益生菌的临床前和临床研究.
- 阐明益生菌可以治疗肝脏疾病的机制.
- 讨论目前在肝病管理中使用益生菌的局限性和未来方向.
主要方法:
- 科学文献的系统审查.
- 临床前 (动物) 和临床 (人类) 研究的分析.
- 生物信息学方法探索益生菌机制.
主要成果:
- 益生菌在通过调节肠道微生物群和影响肠肝轴来管理各种肝胆道疾病方面表现出潜力.
- 特定的益生菌菌株和组合显示出有前途,正在研究它们的作用机制.
- 有证据表明,益生菌可以作为一种有价值的辅助疗法,尽管疗效因病情和菌株而异.
结论:
- 益生菌代表了肝胆道疾病的有希望的治疗策略,准肠道失调和肠肝轴.
- 进一步的研究对于确定临床应用的最佳菌株,剂量和治疗持续时间至关重要.
- 专注于益生菌的安全性,活力和稳定性对于开发肝脏疾病的有效和可靠治疗至关重要.
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