不同治疗方法对牛皮患者的氧平衡的影响
Marija V Medovic1,2, Vesna M Milicic1,2, Ana B Ravic Nikolic1,2
1Department of Dermatovenerology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
生物疗法如seukinumab和ustekinumab在治疗牛皮方面显示出比甲醇更好的抗氧化作用. 这些治疗改善了氧化应激生物标志物,并减少了疾病的严重程度.
科学领域:
- 皮肤病学 皮肤病学
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
背景情况:
- 氧化应激是牛皮发育的一个关键因素.
- 了解其对生物标志物的影响对于有效治疗至关重要.
研究的目的:
- 评估甲索特雷克萨特,塞库金努马布和乌斯特基努马布对牛皮患者氧化应激生物标志物的影响.
- 为了比较这些治疗策略的抗氧化疗效.
主要方法:
- 分析了78名牛皮患者和15名健康对照.
- 血液样本被评估为氧化应激 (TBARS,NO2-,O2-,H2O2) 和抗氧化剂 (SOD,CAT,GSH) 的生物标志物.
- 测量是在基线,16周,28周和52周进行的.
主要成果:
- 与对照组相比,牛皮患者的O2和SOD水平发生了变化.
- 甲二甲酸降低了催化酶活性,降低了谷氨水平.
- 乌斯特基努马布在52周后增加了谷氨水平.
- 所有治疗都减少了牛皮的面积和严重程度指数 (PASI),身体表面积 (BSA),皮肤病生命质量指数 (DLQI) 和湿疹面积和严重程度指数 (EASI).
结论:
- 生物药物 (secukinumab, ustekinumab) 显示其抗氧化作用优于甲醇.
- 这些发现强调了氧化应激在牛皮病原和治疗反应中的作用.
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