将功能性胃肠道疾病置于炎症性疾病的范围内,可以改善这些疾病的分类和诊断
Dunja Šojat1, Mile Volarić1,2, Tanja Keškić3
1Department of Family Medicine, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, J. Huttlera 4, 31000 Osijek, Croatia.
功能性胃肠道疾病 (FGIDs) 涉及复杂的相互作用. 通过神经内分泌,免疫,代谢和微生物组途径观察FGID,可以对慢性炎症和改进的治疗策略提供新的见解.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 微生物学 微生物学
背景情况:
- 功能性胃肠道疾病 (FGIDs) 的症状和患者背景各异,使诊断和治疗复杂化.
- FGIDs的危险因素正在扩大,低水平的慢性炎症被认为是核心的病理生理过程.
- 肠-大脑轴框架突出了神经系统,肠道功能和微生物群之间的复杂相互作用.
研究的目的:
- 为了解FGIDs提出一个网络假设,整合神经内分泌,免疫,代谢和微生物组通路.
- 在许多慢性健康状况中常见的全身慢性炎症的背景下重新定义FGID.
- 通过将炎症标志物与临床和心理社会数据相关联,提高对FGID病变的理解.
主要方法:
- 对FGID病理生理学,炎症和肠-大脑轴的现有文献的综述.
- 综合了与FGID相关的神经内分泌,免疫学,代谢和微生物组研究数据.
- 基于网络相互作用和系统性炎症的概念框架开发.
主要成果:
- 可以将FGID概念化为由相互连接的神经内分泌,免疫,代谢和微生物通路引起的疾病.
- 慢性炎症是FGID发病的一个普遍因素,将其与其他系统性慢性疾病联系起来.
- 将炎症标志物与症状,并发症和心理社会数据相聚,可以揭示FGID子类.
结论:
- 将FGID视为网络障碍提供了更全面的病理生理学理解.
- 在FGID中识别患者子类可以减少异质性,并指导个性化治疗方法.
- 整合多系统数据的进一步研究对于推进FGID诊断和治疗至关重要.
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