选择签名揭示了康沃尔郡公特定品种表型的候选基因
Minja Zorc1, Tajda Horvat1, Anja Tanšek1
1University of Ljubljana, Biotechnical Faculty, Jamnikarjeva ulica 101, 1000 Ljubljana, Slovenia.
Genes
|March 28, 2024
概括
遗传分析显示,LPAR6基因的删除导致康沃尔郡猫独特的rexoid外套. 在他们的基因组中发现了选择特征,但与ALX1基因无关.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 动物育种 动物育种
- 分子生物学分子生物学
背景情况:
- 特定的特征,如外套颜色和形态,在整个猫种中都是常见的.
- 影响毛皮纹理的rexoid突变在几个家猫品种中被发现.
- 康沃尔郡雷克斯 (Cornish Rex) 品种表现出独特的雷克索形毛皮和独特的身体特征.
研究的目的:
- 为了调查康沃尔郡雷克斯品种独特特征的遗传基础.
- 在康沃尔郡的基因组中,在选择性压力下识别基因.
- 确认LPAR6和ALX1基因在康沃里奇鱼特征中的作用.
主要方法:
- 对20只康沃里奇雷克斯猫和4只F1杂交猫进行基因定型,以删除LPAR6基因.
- 使用Runs of Homozygosity (ROH) 岛屿的全基因组选择特征分析和在11只康威尔郡猫的SNP阵列数据上集成的单 haplotype得分 (iHS).
- 将遗传数据与已知的基因功能进行比较,包括缅甸猫的ALX1.
主要成果:
- 在Cornish Rex猫和杂交物中证实了LPAR6基因中的四个基对删除,导致过早停止子.
- 全基因组分析发现了A1,A3,C2,B1,B4和D1.1染色体上的显著选择特征.
- 在研究的康沃尔郡猫中,没有发现ALX1基因的删除.
结论:
- 在LPAR6基因中发现的缺失是康威尔郡猫的rexoid外套表型的原因.
- 选择性压力已经塑造了康沃尔郡的基因组的特定区域.
- ALX1基因与康威尔郡猫的回形毛皮或其他研究的特征无关.
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