台湾的皮使用者的寻找药物的行为和相关特征 - - 一个共享患者网络分析
Yi-Ju Pan1,2, Sheng-Hsuan Chang3, Wei-Chen Lee1
1Department of Psychiatry, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan.
Healthcare (Basel, Switzerland)
|March 28, 2024
概括
高剂量佐洛皮的使用正在增加,男性和患有慢性疾病的人面临更高的风险. 高剂量使用者经常访问多个医疗机构以获得处方.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 医疗服务研究 医疗服务研究
背景情况:
- 在全球范围内,失眠的患病率正在增加,与索尔皮德姆处方的增加并行.
- 了解皮使用升级的驱动因素,特别是高剂量处方,对于公共卫生至关重要.
- 台湾观察到皮处方的显著增加,需要对处方模式进行调查.
研究的目的:
- 确定台湾高剂量佐洛皮使用的社会人口统计和临床决定因素.
- 分析低剂量与高剂量皮使用者的药物寻找模式.
- 探索医疗机构和专业网络在皮使用中的作用.
主要方法:
- 利用台湾国家健康保险研究数据库进行大规模的回顾性研究.
- 采用多重逻辑回归来分析与低剂量和高剂量皮使用相关的因素.
- 应用社交网络分析,在医疗保健提供者之间绘制药物寻找行为.
主要成果:
- 在5290名参与者中,有22.82%被确定为高剂量皮的使用者.
- 男性性别 (OR=1.33) 和慢性疾病的存在 (OR=4.27) 显著增加了使用高剂量皮的风险.
- 高剂量使用者表现出更高的网络密度,表明对皮的不同医疗机构的访问更频繁.
结论:
- 个人因素,包括男性性别和慢性病并发症,是高剂量皮使用的关键驱动因素.
- 高剂量佐洛皮的使用者在多个医疗保健机构中表现出复杂的药物寻找行为.
- 建议包括更严格的处方法规,关于失眠管理的公共卫生教育,以及对潜在的佐洛皮成的加强专业培训.
相关概念视频
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
171
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
171
01:19Management of Insomnia
244
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
244
01:23Sedatives and Hypnotics: Overview
358
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
358
01:19Sedatives and Hypnotics Drugs: Benzodiazepines
243
Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
243
01:14CNS Depressants: Barbiturates and Benzodiazepines
259
CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...
259
01:17Sleepwalking and Sleep Talking
158
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
158