患有阻塞性睡眠呼吸暂停的患者的嗜睡和维生素D水平
Kostas Archontogeorgis1, Nicholas-Tiberio Economou1, Panagiotis Bargiotas2
1Department of Pneumonology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Healthcare (Basel, Switzerland)
|March 28, 2024
概括
低维生素D水平与阻塞性睡眠呼吸暂停 (OSA) 患者的过度白天嗜睡 (EDS) 有关. 睡眠缺氧可能有助于这种关联,强调维生素D状态在OSA管理中的重要性.
科学领域:
- 内分泌学和睡眠医学 睡眠医学
- 营养科学与睡眠障碍 营养科学与睡眠障碍
背景情况:
- 阻塞性睡眠呼吸暂停 (obstructive sleep apnea,OSA) 是一种普遍存在的睡眠障碍,其特点是睡眠期间重复出现上呼吸道阻塞.
- 过度的白天嗜睡 (EDS) 是患有OSA的患者常见的,经常使人衰弱的症状.
- 维生素D缺乏与各种健康状况有关,其在睡眠障碍中的作用是新兴的研究领域.
研究的目的:
- 在被诊断为阻塞性睡眠呼吸暂停 (OSA) 的患者中,研究血清25-氧维生素D[25(OH) D]水平和过度白天嗜睡 (EDS) 之间的关联.
- 探索维生素D状况,睡眠参数和OSA队列中的嗜睡严重程度之间的关系.
主要方法:
- 涉及新诊断的OSA患者的横截面研究,根据EDS的存在或不存在进行分层 (埃普沃思睡眠度量表[ESS]>10对<10).
- 所有参与者都接受了夜间多睡眠图,以评估与睡眠相关的参数.
- 使用放射性免疫检验量化血清25 (((OH) D水平.
主要成果:
- 与非睡眠患者相比,患有EDS的患者表现出显著更高的呼吸暂停-呼吸暂停指数 (AHI) 值和较低的血清平均25(OH) D水平.
- 在EDS患者中,血清25(OH) D水平与ESS得分,AHI和兴奋指数呈负相关性,与平均氧血球和呈正相关性.
- 血清维生素D水平被确定为OSA患者EDS的独立预测因子,较低水平与睡眠增加有关.
结论:
- 阻塞性睡眠呼吸暂停患者的过度白天嗜睡与血清维生素D水平降低有关.
- 睡眠缺氧,通过降低氧血球和表示,可能在维生素D状态和OSA中EDS之间的关系中发挥重要作用.
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