克洛夫卢卡班照亮了PINK1-帕金通路的特异性和上下文依赖激活,通过线粒体复合体抑制

Adrian T Ramirez1, Zeyu Liu1, Quanbin Xu1

  • 1Department of Biochemistry, Jennie Smoly Caruthers Biotechnology Building, University of Colorado-Boulder, 3415 Colorado Ave, Boulder, CO 80303, USA.

Biomolecules
|March 28, 2024
PubMed
概括

研究人员发现,cloflucarban通过抑制线粒体复合体来激活PTEN诱导的激酶1 (PINK1) -帕金因通路. 这种抗菌化合物是研究线粒体质量控制的可靠工具,不受常见培养媒介组件的影响.

相关概念视频

Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
13.2K
The Electron Transport Chain01:30

The Electron Transport Chain

The electron transport chain or oxidative phosphorylation is an exothermic process in which free energy released during electron transfer reactions is coupled to ATP synthesis. This process is a significant source of energy in aerobic cells, and therefore inhibitors of the electron transport chain can be detrimental to the cell's metabolic processes.
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
16.7K
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
134