非编码RNAs:在眼血管疾病中的巨细胞平衡的新型调节者
Qiuyang Zhang1,2, Qing Liu1,2, Siguo Feng1,2
1Affiliated Eye Hospital, Nanjing Medical University, Nanjing 210029, China.
Biomolecules
|March 28, 2024
概括
功能障碍的巨细胞有助于眼睛的新血管化. 非编码RNAs (ncRNAs) 调节巨细胞稳态,为危及视力的血管疾病提供潜在的治疗点.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 眼部新血管化显著影响视力和生活质量.
- 驱动眼部新血管化的确切机制尚不清楚.
- 巨细胞是关键的先天性免疫细胞,参与炎症和组织修复.
研究的目的:
- 审查非编码RNAs (ncRNAs) 在巨细胞平衡中的调节作用.
- 探索ncRNA介导的巨细胞功能障碍在眼血管疾病中的参与.
主要方法:
- 现有研究的文献综述.
- 对ncRNA和巨细胞生物学研究的分析.
- 综合与眼血管疾病相关的发现.
主要成果:
- 巨细胞平衡对于预防眼血管疾病至关重要.
- 非编码RNAs (ncRNAs) 是巨细胞功能和恒温的关键调节者.
- 异常的ncRNA表达涉及到眼部新血管化的病变发生.
结论:
- 对ncRNAs的调节失调会影响巨细胞的稳态,从而导致眼球新血管化.
- 准ncRNAs为治疗眼血管疾病提供了一个潜在的策略.
- 对ncRNA-巨细胞相互作用的进一步研究是治疗开发的必要条件.
更多相关视频
09:36Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
Published on: February 5, 2019
8.7K
07:46Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
25.3K
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
01:24Regulation of Angiogenesis and Blood Supply
2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
01:22MicroRNAs
21.3K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.3K