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封装橄 (Olea europaea L.) 通过超临界CO2技术修剪废物颗粒
Antonio Montes1, Diego Valor1, Ignacio García-Casas1
1Department of Chemical Engineering and Food Technology, Faculty of Sciences, Wine and Agrifood Research Institute (IVAGRO), University of Cadiz, 11510 Cadiz, Spain.
Foods (Basel, Switzerland)
|March 28, 2024
概括
超临界技术被用来封装来自修剪废物的抗氧化橄叶颗粒. 这一过程产生了具有增强抗氧化特性和受控释放配置文件的亚微粒,用于治疗应用.
科学领域:
- 农业科学 农业科学
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 橄叶 (Olea europaea L.) 富含生物活性化合物,具有多种药理活性,包括抗氧化,抗病毒和抗炎性质.
- 之前的研究表明,使用超临界抗溶剂提取方法,橄叶中抗氧化剂亚微粒的沉.
- 封装是一种有价值的技术,用于控制药物输送,使药物释放延迟并减轻医学疗法的第一步效果.
研究的目的:
- 用超临界技术封装来自橄修剪废物的抗氧化物颗粒.
- 研究操作变量 (压力,温度,提取物-聚合物比率) 对封装过程的影响.
- 描述封装颗粒的形态,抗氧化能力和释放特征.
主要方法:
- 超临界流体技术用于对抗氧化剂橄叶提取物进行封装.
- 扫描电子显微镜 (SEM) 用于分析封装物体的形态和大小.
- 使用DPPH试验量化了抗氧化能力,并评估了多含量.
- 实验室释放研究是在模拟的胃和肠介质中进行的.
主要成果:
- 成功获得了从1到5微米大小的封装物.
- 大多数封装产品表现出中等的抗氧化能力,AAI值在0.5到1之间.
- 1:3的提取物-聚合物比率显示了聚醇含量的增加.
- 聚合物封装在模拟的胃条件下有效减缓化合物释放,并在模拟的肠液中提高溶解度.
结论:
- 超临界封装是一种有效的方法,可以从橄修剪残留物中产生抗氧化剂颗粒.
- 该过程允许开发具有可调节释放配置文件的颗粒,适合各种应用.
- 这种方法提供了一种可持续的方式,将橄废弃物利用成高价值的功能成分.
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