绝经后妇女的激素替代疗法和胃衰竭之间的关联:全球数据库分析
Jacqueline Khalil1, Hannah Hill2, David Kaelber3
1Department of Internal Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH 44109, USA.
Journal of personalized medicine
|March 28, 2024
概括
激素替代疗法 (HRT) 与绝经后妇女胃衰竭诊断的风险更高有关. 这项研究发现HRT与胃肠道症状增加和胃的诊断测试有关.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 妇女健康 妇女健康
背景情况:
- 胃衰竭的患病率在女性中更高,女性性激素被假定是导致因素.
- 绝经后的女性代表着经历激素变化的重要人口统计,并面临各种健康状况的风险.
研究的目的:
- 调查激素替代疗法 (HRT) 与绝经后妇女中胃衰竭诊断风险之间的关联.
- 检查HRT对胃衰减相关症状,药物使用和诊断程序的影响.
主要方法:
- 使用TriNetX平台进行的一项基于人口的队列研究,涉及50岁以上的绝经后妇女.
- 用一比一的倾向分数匹配来控制诸如年龄,种族,种族,糖尿病,BMI和HbA1c等混因素.
- 排除标准包括功能性消化不良,周期性吐综合征和之前的外科手术.
主要成果:
- 在匹配后,HRT组中有67,874名女性,非HRT组中有67,874名女性.
- HRT与胃衰竭诊断的风险增加有关 (OR = 1.23,p=0.0395),这种联系持续了5年 (OR = 1.65,p=0.0086).
- HRT也与早期腹感的增加相关 (OR = 1.22,p=0.0187),多佩里的使用 (OR = 2.40,p=0.0163),以及胃空化的研究 (OR = 1.67,p<0.0001).
结论:
- 激素替代疗法与绝经后妇女患胃衰竭诊断的风险增加有关.
- 使用HRT可能会加剧或导致胃肠道症状,需要进一步对胃的诊断评估.
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