炎症的表现取决于宫癌的阶段
Agne Vitkauskaite1, Daiva Urboniene2, Joana Celiesiute1
1Department of Obstetrics and Gynaecology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50161 Kaunas, Lithuania.
Medicina (Kaunas, Lithuania)
|March 28, 2024
概括
系统性炎症标志物,包括互白素-6 (IL-6),TREM-1和脂素-2 (LCN2),可以预测宫癌 (CC) 风险. 升高的IL-6和LCN2水平也表明晚期CC的可能性更高.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 子宫癌 (CC) 是一个重要的全球健康问题,特别是对女性来说.
- 慢性炎症与CC的发展有很大关系.
- 了解系统性炎症的作用对于早期检测和预后至关重要.
研究的目的:
- 为了评估CC患者的全身炎症标志物.
- 确定这些标志物的预后价值,用于CC和高级阶段.
- 确定炎症标志物作为预测剂的特定值.
主要方法:
- 在94名CC患者和88名健康对照人群中测量了血清细胞因子度.
- 分析的细胞因子包括IFN-β,IFN-γ,IL-1β,IL-2,IL-6,IL-10,IL-12p70,LCN2,TREM-1和TNF-α. 在这些细胞因子中,
- 统计分析确定了CC和高级阶段CC组中炎症标志物水平的概率比率.
主要成果:
- 升高的IL-6 (>17.4 pg/mL),TREM-1 (>355.6 pg/mL) 和LCN2 (>23,721.5 pg/mL) 显著增加了患有CC的几率.
- 较高的IL-6 (>28.7 pg/mL) 和LCN2 (>25,640.0 pg/mL) 水平预测了晚期的CC (III-IV).
- 患有CC的患者表现出较高的全身炎症,与疾病的存在和阶段相关.
结论:
- 治疗前IL-6,TREM-1和LCN2的血清水平可以作为宫癌的预测指标.
- IL-6和LCN2是晚期宫癌的有价值预测剂.
- 系统性炎症是CC发育和进展的关键因素.
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