乳清可以通过强烈调节小鼠肌细胞分化来缓解肌肉缩
Jin A Lee1,2, Mi-Rae Shin1, Minju Kim2
1Department of Herbology, Daegu Haany University, Deagu 42158, Republic of Korea.
Medicina (Kaunas, Lithuania)
|March 28, 2024
概括
乳清 (WP) 补充剂显著抵消小鼠的肌肉缩. 这项研究表明,WP改善肌肉质量和蛋白质平衡,为肌肉消耗条件提供了潜在的治疗方法.
科学领域:
- 肌肉生理学和生物化学
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肌肉缩,以失衡的蛋白质平衡为特征,是一个日益严重的公共卫生问题.
- 它导致肌肉功能受损,肌肉质量减少.
研究的目的:
- 研究乳清 (WP) 在减轻小鼠中德甲 (DEX) 诱导的肌肉缩的疗效.
主要方法:
- 在C57BL/6小鼠中,口服WP持续6周.
- 通过腹腔内注射诱导肌肉缩使用德甲 (DEX).
- 微计算机断层扫描 (CT) 和组织染色被用于分析.
主要成果:
- WP显著增加了小牛肌肉体积,肌肉纤维面积和原沉积.
- WP降低了肌肉损伤,功能和炎症的血清生物标志物.
- WP调节了IGF-1/PI3K/Akt和FOXO通路,增加了合成代谢信号传递和降低了代谢.
结论:
- 乳清 (WP) 通过恢复肌肉蛋白质平衡,有效降低肌肉缩.
- WP促进肌细胞分化,这表明它在预防和治疗肌肉衰竭方面发挥了作用.
- 作为治疗肌肉缩的治疗补充剂,WP显示出前景.
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