对于区分阿尔茨海默氏病和前性痴呆变体的无动作模式
Georgios Papadopoulos1,2, Dimitrios Parissis1, Anna Gotzamani-Psarrakou3
12nd Department of Neurology, AHEPA University Hospital of Thessaloniki, 54636 Thessaloniki, Greece.
Medicina (Kaunas, Lithuania)
|March 28, 2024
概括
性评估有效地区分了阿尔茨海默病 (AD) 和前性痴呆症 (FTD) 亚型. 分析无力症概况,包括肢体,语言和非语言,有助于诊断痴呆症,并与认知能力下降相关联.
科学领域:
- 神经学 神经学
- 认知神经科学 认知神经科学
- 老年病的医生 老年病的医生
背景情况:
- 区分阿尔茨海默氏症 (AD),行为变体前性痴呆症 (bvFTD) 和初级渐进性失声症 (PPA) 是具有挑战性的,即使有生物标志物.
- 阿普拉西亚是阿尔茨海默病的支持性诊断特征,在其他类型的痴呆症中通常代表性不足.
研究的目的:
- 在AD,bvFTD和PPA中调查四肢,口头和非口头无动感的存在和特征概况.
- 为了评估诊断准确性和预测价值的无修形状在区分这些类型的痴呆症.
主要方法:
- 对患有AD,bvFTD,PPA和健康对照 (HC) 的患者进行了上肢无效的测试 (TULIA) 和成年人的无效电池-2 (ABA-2).
- 在患者组和HC之间比较综合和子域无习惯性得分.
- 分析了诊断指标的实践概况.
主要成果:
- 与HC相比,Apraxia评估表明痴呆症检测的诊断准确度很高 (灵敏度:63.6-100%,特异性:79.2-100%).
- 与bvFTD相比,患有AD的患者在模仿和模姿态方面表现出更大的缺陷.
- 与AD相比,PPA患者表现出言语和非言语不适的病理结果增加,尽管总体下降较大,但与bvFTD相比,实践结果相似.
- 与AD相比,bvFTD患者在口头无力症中表现出更高的病理结果.
- 失调症的严重程度与认知能力下降相关.
结论:
- 吸食性表现的评估可以帮助区分AD和FTD亚型.
- TULIA和ABA-2是临床实践中可靠的临床测试,用于评估痴呆症中的失调.
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