自闭症谱系障碍及其在怀孕期间可能的起源
Rayane M Botelho1, Ana Lúcia M Silva1, Alexandre U Borbely1
1Cell Biology Laboratory, Institute of Biological and Health Sciences, Federal University of Alagoas, Maceio 57072-970, Brazil.
概括
孕妇在怀孕期间暴露于环境危害可能会增加儿童患自闭症谱系障碍 (ASD) 的风险. 本综述探讨了与自闭症发展相关的妊娠因素,以帮助医疗保健专业人员确定风险和预防策略.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿科健康 儿科健康
- 环境流行病学环境流行病学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种普遍的神经发育障碍,在全球范围内影响着大约100分之一的儿童.
- 诊断ASD需要持续的社会沟通和互动的缺陷,以及受限制的,重复的行为.
- 自闭症的确切原因仍然不确定,有证据表明多因素的起源,包括产前环境暴露.
研究的目的:
- 审查当前关于可能与ASD发展相关的妊娠因素的科学文献.
- 为了确定孕妇在怀孕期间可能作为ASD风险因素的孕产妇暴露.
- 为医疗专业人员提供有关ASD预防和管理的最新信息.
主要方法:
- 对产前暴露和ASD最近研究的系统文献综述.
- 分析数据,将母亲的孕期暴露 (生物,化学,物理) 与胎儿神经发育联系起来.
- 综合了对环境危害影响母胎二和ASD结果的发现.
主要成果:
- 孕期母亲暴露在各种环境危害中,越来越多地与胎儿神经发育的改变有关.
- 怀孕期间遇到的特定生物,化学和物理因素被认为是导致ASD的因素.
- 环境压力因素对母胎平衡的破坏可能会对神经发育轨迹产生负面影响.
结论:
- 孕期环境暴露是理解ASD病因学的重要研究领域.
- 识别这些产前风险因素对于制定有针对性的预防和干预策略至关重要.
- 需要进一步的研究来阐明确切的机制,将母亲的暴露与ASD发展联系起来.
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