结构,抗氧化活性和抗微生物研究的光兰化物复合体与p-酸的抗菌学研究
Grzegorz Świderski1, Ewelina Gołębiewska1, Natalia Kowalczyk1
1Department of Chemistry Biology and Biotechnology, Bialystok University of Technology, Wiejska 45E, 15-351 Bialystok, Poland.
Materials (Basel, Switzerland)
|March 28, 2024
概括
抗氧化剂和抗微生物特性:p-酸的兰化物复合体表现出增强的抗氧化和抗微生物特性. 这些金属复合体表现出较好的激素清除和更大的有效性与细菌和真菌相比,与自由连接体.
科学领域:
- 协调化学 协调化学
- 材料科学 材料科学 材料科学
- 生物化学 生物化学
背景情况:
- 酸 (p-CAH2) 是一种具有已知的生物活性的化合物.
- 兰化物离子因其独特的电子和协调性质而被探索.
- 研究金属联结体复合物可以带来具有增强功能的新材料.
研究的目的:
- 用p-coumaric酸合成和表征兰化物复合物.
- 评价兰化物离子 (Ce3+,Pr3+,Nd3+,Sm3+) 对p-酸电子结构,抗氧化剂和生物特性的影响.
- 评估合成复合物的热稳定性和抗微生物疗效.
主要方法:
- 用于结构分析的光谱技术 (FTIR,ATR,UV).
- 热分析 (TG,DTG,DSC) 用于研究降解行为.
- 抗氧化剂测试 (DPPH,ABTS,OH激素清除,CUPRAC) 和抗微生物测试 (MIC,MTT测试) 对各种微生物进行.
主要成果:
- 兰化物离子通过双双化模式与p-酸协调,形成具有更高热稳定的水合复合物.
- 复杂化增强了p-酸pi电子系统的芳香度.
- 与自由配体相比,兰化物复合物显著改善了抗氧化活性,特别是对基激素,以及对大肠杆菌,B. subtilis和C. albicans的优越抗微生物疗效.
结论:
- 兰化物复合修改了电子结构,并增强了p-酸的抗氧化和抗微生物特性.
- 合成的复合物代表了需要强大的抗氧化剂和抗菌剂的应用的有希望的候选人.
- 对这些金属有机化合物的进一步研究可能会开启新的治疗和材料科学应用.
相关概念视频
03:02Colors and Magnetism
11.7K
Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
11.7K
00:43Complexometric Titration: Ligands
948
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
948
01:42The Antenna Complex
6.0K
Plants and other photosynthetic organisms comprise pigments capable of absorption of direct sunlight. These pigments are present in the reaction center - the main site of photochemical reactions as well as in the antenna complex. Under average light conditions, the rate at which reaction center pigments absorb light is far below the electron transport chain's capacity. As a result, the reaction center alone cannot provide enough energy to drive photosynthesis. The photosynthetic efficiency...
6.0K
01:09Complexation Equilibria: Factors Influencing Stability of Complexes
369
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
369
00:56Extraction: Advanced Methods
446
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
446
01:22EDTA: Chemistry and Properties
1.9K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
1.9K