儿科人口中的乙型肝炎:罗马尼亚的观察性回顾性研究
Daniela Păcurar1,2, Alexandru Dinulescu1,2, Gheorghiță Jugulete3,4
1Department of Pediatrics, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Life (Basel, Switzerland)
|March 28, 2024
概括
这项研究揭示了罗马尼亚大多数儿科慢性乙型肝炎病毒 (HBV) 感染是免疫活性. 家庭HBV感染影响了儿童的诊断年龄和病毒水平.
科学领域:
- 儿科肝病学 儿科肝病学
- 病毒性肝炎的流行病学
- 传染性疾病 传染性疾病
背景情况:
- 慢性乙型肝炎病毒 (HBV) 感染是全球重要的健康问题,特别影响儿童.
- 对于罗马尼亚的儿科慢性HBV队列存在有限的流行病学数据.
- 了解儿科慢性HBV的特征对于有针对性的干预至关重要.
研究的目的:
- 描述罗马尼亚南部儿科慢性HBV感染的流行病学和临床概况.
- 根据血清学,病毒病和肝酶水平来识别不同的疾病状态.
- 探索人口因素,家庭感染,共感染和实验室参数之间的相关性.
主要方法:
- 在506名被诊断患有慢性HBV感染的儿童中进行了观察性回顾性研究.
- 疾病状态是使用阿氨酸转移酶 (ALT) 水平,HBV血清学和HBV DNA (病毒性病) 来定义的.
- 统计分析将年龄,性别,家庭HBV状况和共感染 (包括D型肝炎病毒 - HDV) 与实验室发现相关联.
主要成果:
- 大多数儿童 (65.4%) 呈现出一种免疫活性状态,其特征是阳性乙型肝炎e抗原 (HBeAg),高ALT和高病毒血.
- 家庭HBV感染的儿童在显著年轻时被诊断出HBV感染,并呈现出较高的病毒血量.
- 与HBV单一感染相比,HBV-HDV共感染与显著更高的ALT值有关.
结论:
- 罗马尼亚南部的儿童慢性HBV感染主要处于免疫活性阶段.
- 家庭传播在早期诊断和儿童病毒载量增加方面发挥着作用.
- 虽然HBV和HDV共感染率显著,但它们似乎低于罗马尼亚普通人口.
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