久坐不动行为和屏幕时间与人类肠道微生物组合和多样性的关联
Maximilian T Antush1, Onesmo B Balemba2,3, Sarah A Hendricks4
1Department of Movement Sciences, University of Idaho, Moscow, ID 83843, USA.
Life (Basel, Switzerland)
|March 28, 2024
概括
久坐不动的行为和屏幕时间会对肠道微生物群的多样性和组成产生负面影响. 这些生活方式因素可能会通过肠道微生物群的改变增加2型糖尿病的风险.
科学领域:
- 微生物组研究的研究.
- 人类健康 人类健康 人类健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肠道微生物组组成影响宿主健康,包括代谢控制.
- 身体活动和肠道微生物群之间的关联已知,但与久坐行为和屏幕时间的联系需要进一步调查.
- 血糖控制受损是2型糖尿病的危险因素.
研究的目的:
- 调查成年人静坐行为,屏幕时间和肠道微生物群α多样性和组成之间的关系.
- 探索这些关联在有或没有血糖控制受损的个体中.
主要方法:
- 调查收集了47名成年人的久坐行为和屏幕时间数据.
- 分析了便微生物DNA,以确定肠道微生物组合和α多样性.
- 统计分析评估了协会,控制了相关的共变量.
主要成果:
- 久坐不动的行为与微生物丰富性 (观察到的OTU,Chao 1) 和多样性 (费舍尔的阿尔法) 有显著的负面关联.
- 屏幕时间与观察到的OTU,香农指数和费舍尔的α指数有负相关性,在同变量调整后,只有OTU关联仍然显著.
- 这些负面关联表明肠道微生物多样性的减少和组成的改变,随着久坐行为和屏幕时间的增加.
结论:
- 久坐不动的行为和屏幕时间似乎是影响人类肠道微生物群组成和多样性的重要因素.
- 这些发现表明,通过肠道微生物组失调症,可能存在一种机制,将久坐不动的生活方式与2型糖尿病风险增加联系起来.
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