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胚胎培养-形态动力学和环境稳定性的时间延迟化可能不足:试点随机对照试验的结果
Gilat C Sacks1, Henny Mozes1, Ruth Ronn1
1Shaare Zedek Medical Center, In Vitro Fertilization Unit, Jerusalem 9103102, Israel.
Journal of clinical medicine
|March 28, 2024
概括
时间间隔化器 (TLI) 并没有显著改善生殖结果. 无论是不受干扰的培养还是形态动力学胚胎分类,TLI的关键组成部分,都没有在这个试点研究中显示出任何附加值. 需要进一步验证.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 在体外受精过程中受精.
背景情况:
- 评估时间间隔化器 (TLI) 技术在辅助生殖技术中的价值.
- 研究未受干扰的胚胎培养和形态动力学分析对生殖成功的独立贡献.
研究的目的:
- 确定TLI技术的组件 (不受干扰的培养和形态动力学分级) 是否为生殖结果提供额外的好处.
- 为了比较常规化和TLI系统之间的活产率和妊娠结果.
主要方法:
- 未来的,随机的,受控的,双盲的,单中心的试点研究 (2016-2020).
- 102名患者被随机分为三个组:常规化,TLI与全面评估,TLI仅与形态评估.
- 对1061个成熟卵细胞的评估,重点关注活产率,怀孕率和胚胎质量.
主要成果:
- 单个 (35%对31.6%对24%) 或双重胚胎移植周期 (41.7%对38.5%对36.4%) 的活产率没有显著差异.
- 在所有组中可比较高质量的胚胎的怀孕,临床怀孕和累积怀孕率.
- 形态动力学评分仅在5.6%的病例中可能改变治疗计划,怀孕结果没有变化.
结论:
- TLI的各个组成部分,即不受干扰的培养和形态动力学胚胎分类,似乎没有显著提高生殖结果.
- 该研究表明,TLI技术可能无法提供超越传统方法的实质性附加价值.
- 结果需要通过更大的随机对照试验 (RCT) 进行验证.
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