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通过被动听力fMRI进行语言侧向化,用于对叶的术前评估:单中心回顾性研究

Yoji Okahara¹, Kyoko Aoyagi¹, Hiroto Iwasa²

¹Department of Neurological Surgery, Chiba Cerebral and Cardiovascular Center, Chiba 290-0512, Japan.

Journal of clinical medicine

|March 28, 2024

概括

一种新的被动功能性MRI (fMRI) 方法可以准确地评估患者的语言功能,包括那些有智力障碍的人,帮助进行术前规划. 这种方法提供了一种安全有效的替代方案,用于语言横向化的活跃任务.

科学领域:

神经科学是一个神经科学.
发病学 (Epileptology) 是一个专业的学科.
医疗成像医学成像

背景情况:

术前语言功能障碍风险评估在叶 (TLE) 中至关重要.
功能性MRI (fMRI) 是语言横向化的一个关键的非侵入性工具.
现有的活跃的fMRI范式对儿科和智力障碍患者构成挑战.

研究的目的:

用一种被动叙事倾听fMRI范式来评估语音理解.
评估日语TLE患者的语言功能和侧面化.
为了确定被动fMRI在智力障碍患者的疗效.

主要方法:

21名耐药性TLE患者参与了这项研究,其中包括6名智力障碍患者.
在一个块设计fMRI中使用了被动的听觉刺激 (向前,静音,向后播放).
计算了fMRI侧向化指数,并与Wada测试结果进行了比较.

主要成果:

被动fMRI范式与Wada测试实现了95.2%的一致率.
即使在智力障碍的参与者中,也证明了成功的语言功能评估.
该方法在评估语音理解方面被证明是有效的.

结论:

被动叙事倾听fMRI提供了一个安全和可访问的术前语言评估方法.
这种模式对于无法参与活跃的fMRI任务的患者来说尤其有益.
这些发现支持使用被动fMRI来改善TLE手术前规划.

关键词:

Wada Wada 测试测试测试是一种.功能性核磁共振成像 (MRI) 功能性核磁共振成像语言横向化 (lateralization) 是一种语言横向化.消极的听觉刺激是被动的.

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