相关实验视频

Updated: May 1, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

甲状腺结节中的分子细胞学现状:平台及其诊断和治疗效用

Zeina C Hannoush¹, Roberto Ruiz-Cordero², Mark Jara¹

¹Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

Journal of clinical medicine

|March 28, 2024

概括

分子测试有助于管理不确定的甲状腺结节,提供更好的诊断准确性. 这些测试指导临床决策,并可能导致针对特定遗传变化的个性化治疗.

科学领域:

内分泌学在内分泌学.
分子诊断学分子诊断
在瘤学瘤学.

背景情况:

甲状腺结节很常见,导致频繁的细针吸收 (FNA).
大约20%的FNA产生不确定的结果,使患者管理复杂化.
分子测试已经成为澄清不确定的甲状腺FNA结果的宝贵工具.

研究的目的:

审查和比较美国三大领先的商业分子细胞学平台:Afirma GSC,Thyroseq GC和ThyGeNEXT + ThyraMIR.
评估这些分子测试的诊断性能,包括预测值和准确性.
讨论甲状腺结节分子测试的挑战和未来方向.

主要方法:

对 Afirma GSC,Thyroseq GC 和 ThyGeNEXT + ThyraMIR 平台进行比较的审查.
对测试性能指标 (灵敏度,特异性,预测值) 的连续改进进行分析.
检查比较诊断准确性和临床实用性的研究.

主要成果:

阿菲尔玛GSC和Thyroseq GC显示了诊断性能的连续改善.
对比研究表明,Afirma GSC和Thyroseq GC的诊断性能相似,成本和处理时间有所不同.
Thyroseq GC提供了详细的基因组数据和管理指南; ThyGeNEXT + ThyraMIR显示出有前途的结果,特别是在miRNA分析方面.

结论:

分子测试显著有助于诊断和管理不确定的甲状腺结节.
虽然解释和成本效益方面的挑战仍然存在,但这些平台提供了有价值的见解.
进展指向治疗应用,FDA批准的选择针对定制治疗的特定遗传改变.

关键词:

精细的针吸入精细的针.基因分析遗传分析分子细胞学分子细胞学.突变是一种突变.甲状腺癌是一种癌症.甲状腺结节甲状腺结节

更多相关视频

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

相关概念视频

The Thyroid Gland

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...

Hyperthyroidism II: Pathophysiology

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...