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新型合成大麻素效应的时间框架分析:关于行为反应和内源性大麻素干扰的研究

Jorge Carlos Pineda Garcia^1,2, Ren-Shi Li^1,3, Ruri Kikura-Hanajiri⁴

¹Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

International journal of molecular sciences

|March 28, 2024

概括

合成大麻素 (SCs) 会导致显著的行为和认知障碍,包括记忆障碍和运动协调下降. 这些影响与改变的内分泌大麻素水平和随着时间的推移减少脑衍生神经营养因子 (BDNF) 表达相关.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
毒理学毒理学毒理学

背景情况:

合成大麻素 (SCs) 是一种强烈的精神活性物质,以迅速发作和长时间的效果而闻名.
了解MDMB-CHMINACA,5F-ADB-PINACA和APICA等新型SCs的神经生物学影响是非常重要的,因为它们的流行率越来越高.
之前的研究表明,SCs.可能会对内分泌系统 (ECS) 造成破坏.

研究的目的:

为了研究三种新型SCs的行为影响:MDMB-CHMINACA,5F-ADB-PINACA和APICA.
评估SC给药,内分泌大麻素 (EC) 水平和海马体中EC代谢酶的表达之间的相关性.
为了分析这些影响在不同的时间框架 (1,3,和5小时) 后的管理.

主要方法:

给MDMB-CHMINACA,5F-ADB-PINACA和APICA的试验对象进行管理.
评估行为反应,包括机动活动和类似焦虑的行为.
对胺 (AEA) 和2 - 阿拉基醇糖醇 (2-AG) 的海马水平的测量.
对脂肪酸胺酸酶 (FAAH),单糖醇脂酶 (MAGL) 和来自大脑的神经营养因子 (BDNF) 的mRNA表达量的量化.

主要成果:

所有测试的SC都以时间依赖的方式诱导了机动力干扰和类似焦虑的症状.
MDMB-CHMINACA在服用后1小时和3小时显著损害记忆力.
在MDMB-CHMINACA和5F-ADB-PINACA给药1小时后,观察到AEA和2-AG水平升高.
在1小时后注意到FAAH,MAGL和BDNF的mRNA表达减少,FAAH在3小时后仍然减少.

结论:

合成大麻素暴露会导致显著的认知和运动障碍.
增加的内分泌大麻素水平和减少的BDNF表达与SC消费有关.
时间评估框架对于理解合成大麻素的全部影响至关重要.

关键词:

5F-ADB-PINACAA 5F-ADB-PINACAA 5F-ADB-PINACAA 5F-ADB-PINACAA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-PINACA 5F-ADB-ADB-B-B-B-C-C-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-D-在APICAICA中使用APICA.在JWH-01818中使用.在MDMB-CHMINACAAA中使用.行为行为行为行为行为.英达/英达这是一台机车机车.记忆记忆记忆记忆记忆

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