基因甲基化对血管光滑肌肉细胞表型切换的影响
Chanthong Yorn1, Hyunjung Kim1, Kyuho Jeong1
1Department of Biochemistry, College of Medicine, Dongguk University, Gyeongju 38066, Republic of Korea.
International journal of molecular sciences
|March 28, 2024
概括
DNA甲基化影响血管光滑肌细胞 (VSMC) 的可塑性,影响血管重塑. 了解这些表观遗传机制为血管疾病提供了新的治疗点.
科学领域:
- 心血管生物学 心血管生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 细胞生物学 细胞生物学
背景情况:
- 血管光滑肌细胞 (VSMC) 通过收缩和放松来调节动脉功能.
- 大型微粒细胞表现出表型的可塑性,在收缩和合成状态之间切换,影响增殖和迁移.
- 表观遗传机制,特别是DNA甲基化,是VSMC分化和可塑性的关键调节者.
研究的目的:
- 审查DNA甲基化通路在调节VSMC可塑性的作用.
- 总结控制血管重塑的机制通过VSMCs的DNA甲基化.
- 以VSMC表观遗传调节为基础,突出针对血管疾病的潜在治疗点.
主要方法:
- 文献综述侧重于DNA甲基化和VSMC生物学.
- 对控制VSMC表型切换的表观遗传机制的分析.
- 综合当前对DNA甲基化在血管重塑中的作用的理解.
主要成果:
- 基因甲基化,即将甲基组添加到细胞酸中,通过影响转录因子相互作用来调节基因表达.
- 通过DNA甲基化进行表观遗传调节对于控制VSMC分化和表型灵活性至关重要.
- 了解这些途径对于理解血管重塑过程至关重要.
结论:
- DNA甲基化途径是VSMC可塑性和血管重塑的核心.
- 针对VSMC中的表观遗传机制,为新的治疗策略提供了一个有希望的途径.
- 对VSMC表观遗传学的进一步研究可以推进复杂血管疾病的治疗方法.
更多相关视频
09:06Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
8.3K
11:19Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
Published on: September 26, 2015
8.0K
相关概念视频
Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
Regulation of Angiogenesis and Blood Supply
2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Genomic Imprinting and Inheritance
34.4K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.4K
Chromatin Modification in iPS Cells
1.6K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
1.6K
Position-effect Variegation
6.3K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
6.3K
Forced Transdifferentiation
1.9K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
Artificial...
1.9K
