癌症中循环的microRNAs:一个5年更新,重点关注乳腺和肺癌
Dario Siniscalco1,2, Umberto Galderisi1, Gianfranco Peluso3,4
1Department of Experimental Medicine, Division of Molecular Biology, Biotechnology and Histology, University of Campania, 80138 Naples, Italy.
International journal of molecular sciences
|March 28, 2024
概括
循环微RNAs (c-miRNAs) 在癌症研究中表现有前途,特别是在乳腺和肺癌中. 本综述强调了它们在早期检测,治疗耐药性和复发风险方面的作用.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生化学
背景情况:
- 循环微RNA (c-miRNA) 是体液中的非编码RNA,在癌症中具有显著的预后潜力.
- 最近的研究 (2018-2023) 突出了c-miRNAs在理解癌症生物学和进展中的演变作用.
研究的目的:
- 审查癌症中c-miRNAs的最新研究,重点关注高度流行的癌症,如乳腺癌 (BC) 和肺癌 (LC).
- 确定有关瘤学中的c-miRNAs的当前研究趋势和见解.
主要方法:
- 2018年至2023年间在PubMed上发表的150多篇关于c-miRNAs和癌症的论文的叙述性综述.
- 对与乳腺癌和肺癌相关的研究进行了专注的分析,检查了像miR-21和miR-145这样的特定放松调节的c-miRNA.
主要成果:
- 乳腺癌和肺癌是与c-miRNAs相关的最常被研究的癌症.
- 在关键的癌症研究领域,c-miRNAs 已经证明了其有效性:早期检测,治疗耐药性,复发风险评估和新型检测平台.
- 在乳腺癌和肺癌研究中,miR-21和miR-145经常被确定为不受管制的.
结论:
- 循环的microRNA仍然是瘤研究的一个动态和重要的领域.
- 血液是用于癌症中c-miRNA分析的主要生物矩阵.
- c-miRNAs为癌症检测,治疗和预后提供了宝贵的见解,特别是在乳腺和肺癌中.
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