从"Limoncella"果品种中提取的富含多烯的提取物改善了丁二二硫酸诱导的大肠炎和相关的肝损伤
Stefania Lama1, Ester Pagano2, Francesca Borrelli2
1Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via de Crecchio 7, 80138 Naples, Italy.
International journal of molecular sciences
|March 28, 2024
概括
果聚烯提取物 (LAPE) 有效地治疗由炎症性肠病 (IBD) 引起的肝损伤. 这种抗氧化和抗炎化合物在预防IBD相关的肝毒性方面表现有前途.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 炎症性肠病 (IBD) 可以导致肠外并发症,特别是肝损伤 (肝毒性).
- 升高的肝酶 (AST,ALT) 和肝毒性在IBD患者中很常见,影响高达30%.
- 氧化应激和免疫反应的破坏是IBD的关键病理机制.
研究的目的:
- 为了研究果多烯提取物从Malus domestica cv.的疗效. 在治疗IBD诱导的肝毒性时使用"Limoncella" (LAPE).
- 评估LAPE在减轻与炎症性肠道疾病相关的肝损伤方面的潜力.
主要方法:
- 将LAPE (3-300 mg/kg) 通过口腔给患有丁二硫酸 (DNBS) 诱导的大肠炎的小鼠.
- 评估组织性肠损伤,髓氧化酶活性和炎症标志物 (TNF,IL-1β).
- 对血清脂质过氧化,肝损伤标志物和核转录因子-kappaB (NF-κB) 激活的评估.
主要成果:
- 在DNBS诱导的大肠炎中,LAPE显著降低了组织学性肠损伤和髓氧化酶活性.
- 治疗LAPE导致瘤亡因子和白素-1β的表达减少.
- 血清脂质过氧化和肝损伤标志物显著改善,同时NF-κB激活减少.
结论:
- 拉佩显示出显著的抗氧化和抗炎性质.
- 这些特性使LAPE能够有效地预防由炎症性肠病引起的肝损伤.
- 对于IBD相关的肝毒性来说,LAPE是一个潜在的治疗干预措施.
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