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Updated: Jun 29, 2025

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
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针对B细胞恶性瘤中的BTK:从作用方式到抵抗机制

Samir Mouhssine1, Nawar Maher1, Bassam Francis Matti2

  • 1Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale and Azienda Ospedaliero-Universitaria Maggiore della Carità, 28100 Novara, Italy.

International journal of molecular sciences
|March 28, 2024
PubMed
概括

布鲁顿氨酸激酶 (BTK) 抑制剂对B细胞恶性瘤有效,但可能发生耐药性. 正在开发非共价抑制剂和PROTAC等新策略,以克服BTK抑制剂耐药性.

关键词:
降解BTK的降解剂布鲁顿铁氨基酶是什么?慢性淋巴细胞白血病 慢性淋巴细胞白血病扩散大的B细胞淋巴瘤.淋巴细胞性淋巴瘤 淋巴细胞性淋巴瘤覆盖细胞淋巴瘤是什么?

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