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Updated: May 5, 2026

Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice
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Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

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鼠类和人类肌肉细胞中的DUX4-HIF1α轴:比预期更复杂的联系

Thuy-Hang Nguyen1, Maelle Limpens1, Sihame Bouhmidi1

  • 1Laboratory of Respiratory Physiology, Pathophysiology and Rehabilitation, Research Institute for Health Sciences and Technology, University of Mons, 7000 Mons, Belgium.

International journal of molecular sciences
|March 28, 2024
PubMed
概括

面额头骨肌肉发育不良症 (FSHD) 涉及DUX4表达. 这项研究揭示了FSHD中DUX4和HIF1α之间的复杂关系,表明HIF1α向可能对治疗具有挑战性.

关键词:
DUX4X4 的使用情况这是FSHD的FSHD.这就是HIF1α.肌肉发育 (myogenesis) 是一个过程.这是骨肌肉的骨架肌肉.

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