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Updated: Jun 29, 2025

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

在表观遗传学时代的胃癌

Grigorios Christodoulidis¹, Konstantinos-Eleftherios Koumarelas¹, Marina-Nektaria Kouliou¹

¹Department of General Surgery, University Hospital of Larissa, University of Thessaly, Biopolis Campus, 41110 Larissa, Greece.

International journal of molecular sciences

|March 28, 2024

概括

胃癌 (GC) 表观遗传学受到Helicobacter pylori (Hp) 和爱斯坦-巴尔病毒 (EBV) 等感染的影响,涉及DNA甲基化和基因组修饰. 新型表观遗传药物在治疗GC和克服抗药性方面表现有前途.

科学领域:

在瘤学瘤学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
分子生物学分子生物学

背景情况:

胃癌 (GC) 是癌症死亡的主要原因.
表观遗传变化,包括DNA甲基化和基因组修饰,在GC发育和进展中起着至关重要的作用.
诸如Helicobacter pylori (Hp) 和爱斯坦-巴尔病毒 (EBV) 等感染显著影响GC表观遗传学.

研究的目的:

审查导致胃癌发展和进展的表观遗传机制.
突出HP和EBV感染在GC表观遗传学中的作用.
讨论表观遗传生物标志物和治疗GC的潜力.

主要方法:

关于胃癌表观遗传学的当前文献的综述.
分析HP和EBV感染对DNA甲基化和基因素修饰的影响.
探索参与GC表观遗传调节的非编码RNA和酶.

主要成果:

HP感染诱导异常DNA甲基化和慢性炎症,而EBV则通过DNMT失调引发DNA甲基化.
惠普-EBV联合感染与瘤的攻击性行为有关.
基因组修饰,NNMT酶活性和非编码RNAs (lncRNAs,circRNAs,miRNAs) 导致GC发育,转移和治疗耐药性.

结论:

表观遗传失调是胃癌的标志,受到传染病原体的显著影响.
血清和胃液衍生的RNA分子显示出作为GC诊断和预后的非侵入性生物标志物的潜力.
下一代表观遗传药物和向输送系统为克服GC治疗抵抗提供了有希望的治疗策略.

关键词:

通过DNA甲基化.流行病药物流行病药物表观遗传学是指表观遗传学.胃癌胃癌是一种胃癌.基质子的修改基质子的修改这就是miRNAs.没有编码的RNAs.

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