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Updated: Jun 29, 2025

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
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基因组胺H1受体介导的JNK酸化通过Gq蛋白依赖但与阿雷斯无关的途径来调节

Shotaro Michinaga1, Ayaka Nagata1, Ryosuke Ogami1

  • 1Department of Pharmacodynamics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

International journal of molecular sciences
|March 28, 2024
PubMed
概括

组胺H1受体通过Gq蛋白,和PKC激活JNK,独立于逮捕素和GRKs. 这种途径与ERK激活不同,突出了不同的信号机制.

关键词:
Gq 蛋白质是一种蛋白质.c-六月 N-终端酶组织胺H1受体的受体.通过基因激活的蛋白质激酶.蛋白质激酶 C 的蛋白质激酶 C.这是一种β-arrestin2的组合.

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