补充水平上的微量营养素,紧张的结点和上皮屏障功能:叙述性审查
Katherine M DiGuilio1, Elizabeth A Del Rio1, Ronald N Harty2
1Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA.
International journal of molecular sciences
|March 28, 2024
概括
微量营养素,特别是补充剂量,可以重塑紧结 (TJs) 改善上皮屏障功能. 这种方法提供了一种安全,低成本的策略,用于预防和治疗与屏障功能障碍相关的疾病.
科学领域:
- 生理学 生理学 生理学
- 病理学 病理学 病理学
- 营养科学 营养科学
背景情况:
- 由疾病修饰因子驱动的上皮屏障泄漏,是疾病发病率的关键.
- 分区的破坏有助于严重的结果,如COVID-19肺部水积累的情况所示.
- 微量营养素显示出改善屏障功能和减少与疾病相关的妥协的潜力.
研究的目的:
- 提出一个理论,关于如何超饮食微量营养素水平重塑紧结 (TJs) 和增强屏障功能.
- 区分饮食和补充微量营养素水平及其在疾病中的必要性.
- 假设为什么信号传导需要更高的补充剂量来进行临床有益的屏障重塑.
主要方法:
- 现有文献的叙述性审查.
- 分析微量营养素在上皮屏障功能中的作用.
- 在疾病病理生理学中探索TJ复杂动态.
主要成果:
- 疾病修饰剂通过改变TJs来诱导上皮屏障泄漏.
- 补充微量营养素,如维生素D,在COVID-19等条件下显示出临床效用.
- 对于有效的TJ重塑和屏障修复,可能需要更高的补充微量营养素剂量.
结论:
- 微量营养素可以作为预防性和治疗性选择,用于涉及上皮屏障功能障碍的疾病.
- 了解饮食与补充微量营养素水平的差异影响对于治疗应用至关重要.
- 对微量营养素介导的TJ重塑机制的进一步研究是有必要的.
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