大脑的新陈代谢因肥胖而受到性别依赖的方式的改变
Jennifer E Norman1, Dragan Milenkovic2, Saivageethi Nuthikattu1
1Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, 1 Shields Ave, Davis, CA 95616, USA.
International journal of molecular sciences
|March 28, 2024
概括
肥胖对男性和女性的大脑代谢的影响不同,改变特定的代谢物,并影响性别独特的行为. 这突显了肥胖对大脑的性别特异性影响.
科学领域:
- 神经科学是一个神经科学.
- 代谢学 代谢学 代谢学
- 肥胖问题研究研究
背景情况:
- 肥胖与认知能力下降和大脑代谢变化有关.
- 性对这些与肥胖相关的大脑变化的影响仍然在很大程度上是未知的.
研究的目的:
- 研究肥胖对大脑代谢的性别特异性影响.
- 研究肥胖如何影响雄性和雌性小鼠的行为和认知功能.
主要方法:
- 利用液体染色学-质谱学检测男性和女性肥胖 (ob/ob) 和野生类型小鼠的整个大脑中的非向代谢.
- 使用开放现场测试评估行为变化.
- 用Y迷宫和莫里斯水迷宫评估认知功能.
主要成果:
- 肥胖在两性中都显著改变了大脑代谢概况,在男性中观察到的变化更多.
- 在男性 (例如,自由脂肪酸) 和女性 (例如,2-linoleoyl glycerol, taurine) 中,不同类型的代谢产物受到肥胖的独特影响.
- 由于肥胖导致的行为障碍仅在雌性小鼠中明显.
结论:
- 肥胖对大脑新陈代谢的影响主要是性别特异性的.
- 这些发现对于理解肥胖在大脑新陈代谢和性别差异化认知衰退中的作用至关重要.
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