免疫疗法和癌症:多方的视角
Clelia Donisi1, Andrea Pretta1, Valeria Pusceddu1
1Medical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
International journal of molecular sciences
|March 28, 2024
概括
了解为什么一些癌症患者对免疫疗法没有反应至关重要. 新的OMIC方法可以解码瘤免疫微环境 (TIME),以改善患者分层和个性化治疗.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 免疫疗法已经改变了癌症治疗,但在一小部分患者中缺乏有效性.
- 对免疫检查点抑制剂的耐药性是一个重大的临床挑战.
- 了解瘤免疫微环境 (TIME) 是克服治疗耐药性的关键.
研究的目的:
- 审查基于奥米克的新型模型来探索瘤生物学.
- 阐明 TIME 在应对免疫阻塞疗法的作用.
- 为了确定患者分层和个性化癌症治疗的生物标志物.
主要方法:
- 审查关于奥米克技术 (基因组学,转录组学,蛋白质组学等) 的当前文献. ) 的情况.
- 对研究瘤免疫微环境 (TIME) 的研究分析.
- 探索新兴技术及其在癌症研究中的应用.
主要成果:
- 奥米克科学为瘤异质性和免疫细胞透提供了深刻的见解.
- 特定的TIME特征与对免疫治疗的反应或耐药性相关.
- 通过奥米克识别的生物标志物可以预测治疗结果.
结论:
- 在癌症免疫疗法中解码抵抗机制时,新型的奥米克方法至关重要.
- 了解TIME对于开发更有效,个性化的治疗策略至关重要.
- 这些进展有可能显著改变瘤学的临床实践.
相关概念视频
Tumor Immunotherapy
523
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
523
Genomics
36.3K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.3K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Cancer Vaccines
363
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
363


