从童年到青春期的身体组成轨迹与非酒精性脂肪肝疾病风险之间的关系
Gigliola Alberti1, Mariana Faune2, José L Santos2
1Department of Pediatric Gastroenterology and Nutrition, Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.
儿童肥胖与非酒精性脂肪性肝病 (NAFLD) 有关. 从幼儿时代开始的较高体脂测量显著增加了青春期患NAFLD的风险.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 是儿童慢性肝病的首要原因,主要原因是儿童肥胖率上升.
- 了解随着时间的推移身体成分的变化对于预测儿科人口中NAFLD发展至关重要.
研究的目的:
- 分析从童年到青春期的身体组成轨迹.
- 确定这些轨迹与青春期患NAFLD的风险之间的关联.
主要方法:
- 针对784名3岁以上儿童进行的前性队列研究 ("智利生长和肥胖队列研究").
- 每年对营养状况和身体组成进行评估 (腰围,皮肤,DXA体脂肪,无脂肪质量指数,脂肪质量指数).
- 在青春期对NAFLD进行超声波查.
主要成果:
- 在青少年时期,NAFLD的患病率为9.8%.
- 更高的腰围 (从3岁开始),皮肤折叠 (从4岁开始) 和DXA体脂肪 (从12岁开始) 与NAFLD有关.
- 脂肪质量指数 (FMI) 升高的第三种动物显示,青少年NAFLD的几率比率显著增加 (2.19为第二种,6.94为第三种).
结论:
- 儿童体脂肪指标升高 (腰围,皮肤,总体脂肪) 是发展NAFLD的危险因素.
- 儿童时期脂肪质量指数较高与青春期NAFLD风险增加密切相关.
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