在中国学龄前儿童中,多基因风险评分,维生素D状态和BMI-for-Agez评分之间的关系
Luolan Peng1, Tingting Liu1, Chao Han1
1Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Nutrients
|March 28, 2024
概括
保持足够的维生素D水平可能有助于降低中国学龄前儿童的BMI-for-agez分数,这些儿童对肥胖的遗传易感性低至中等. 这项研究探讨了遗传学,维生素D状态和儿童肥胖之间的相互作用.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 营养科学 营养科学
- 遗传学 遗传学 是一个
背景情况:
- 儿童肥胖是一个日益关注的问题,受遗传倾向和维生素D缺乏等营养因素的影响.
- 维生素D状况与多基因儿童肥胖风险相关的具体作用尚不清楚.
研究的目的:
- 研究中国学龄前儿童的遗传因素,维生素D状况和BMI-for-age z-score (zBMI) 之间的关系.
- 为了确定维生素D状况是否会改变多基因风险得分和儿童肥胖之间的关联.
主要方法:
- 分析了1046名中国学龄前儿童 (3.76.6岁).
- 多基因风险评分 (PRS) 用55个与BMI相关的SNP计算.
- 用LC/MS-MS测量的血清25(OH) D水平作为维生素D状态的指数.
主要成果:
- 多基因风险评分 (PRS) 与zBMI正相关 (rS=0.0953,p=0.0022).
- 维生素D的状态 (25(OH) D) 与zBMI负相关 (rS=-0.1082,p=0.0005).
- 在低和中等PRS组中,在缺乏维生素D的学龄前儿童中观察到更高的zBMI. 具有足够维生素D的儿童中与zBMI积极相关的遗传风险.
结论:
- 维生素D状态与中国学龄前儿童的zBMI负相关.
- 适当的维生素D水平可能有助于减轻zBMI在儿童低和中等的遗传易感性肥胖.
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